Technologies
at the heart of every formulation
For over 20 years, Bioformula has been developing proprietary technologies that set a higher standard, thanks to the purity of the raw materials, the rigor of the production process, and the stability of the formulation over time.
Pharmaceutical-grade hyaluronic acid fiber
Premium Technology – Bioformula Products
Most biorevitalizing products on the market use hyaluronic acid powder. Bioformula has chosen a pharmaceutical-grade fiber raw material that, unlike common powder, preserves the structural integrity of the polymer throughout the entire production process.
The result is a high-molecular-weight hyaluronic acid that:
- guarantees unprecedented hygroscopic capacity
- offers prolonged resistance to enzymatic degradation
- ensures a minimal inflammatory profile and total biocompatibility
- reducing the post-treatment tissue reaction
High-molecular-weight polynucleotides—derived from Alaskan salmon
Exclusive Technology – Plenhyage XL Line
The quality of polynucleotides depends on their source. Ours are derived from wild Alaskan salmon, caught in pristine waters and naturally free of hormones, antibiotics, and pollutants from aquaculture—the global gold standard for biological integrity.
The raw material is extracted from salmon gonads certified by the FDA for food use; it is a byproduct of the MSC (Marine Stewardship Council)-certified supply chain and is subject to a comprehensive traceability system.
At the dermal level, high-molecular-weight polynucleotides act as a biomimetic scaffold:
Clinical data show a 115% improvement in hydration levels and a 38% improvement in skin elasticity at 20 weeks, with 63% of patients classified as “very much improved” on the GAIS scale and no treatment-related adverse events.
Isoosmolar formulation at physiological pH
Process Technology — Plenhyage XL Line
Plenhyage XL is designed based on parameters that most products on the market do not simultaneously guarantee. An excellent active ingredient is not enough if the formulation that delivers it does not respect the physiology of the tissues.
For this reason, the solution is calibrated to closely match the natural osmolality of human tissues — the further a formulation deviates from this, the greater the risk of cellular irritation and a burning sensation during injection. The pH is carefully controlled to remain within the optimal physiological range, as values outside this range directly activate pain receptors in the tissues. The chosen carrier is neutral saline, free of unnecessary excipients: maximum concentration of the active ingredient, uniform diffusion, and maintained isotonicity. The result is a more tolerable injection experience — for both the patient and the healthcare professional.
Low BDDE residue
Process Standards — Evanthia Line
BDDE is the standard cross-linker used in the cross-linking of hyaluronic acid, and its residual concentration in the finished product is a key safety parameter.
Evanthia fillers are manufactured in accordance with the most stringent European requirements for Class III Medical Devices (CE 0373). For this reason, BDDE residue is monitored, controlled, and certified for every single batch through an integrated quality system.
Thanks to Bioformula’s vertically integrated production model, control of this parameter is guaranteed at every stage of the process, ensuring high standards of repeatability, traceability, and compliance in every production cycle.
The result is a cross-linked filler with high-performance volumizing and contouring capabilities, capable of combining clinical efficacy with a safety profile that meets regulatory standards and patient expectations.
Quality Control System – Production Standards
Bioformula Infrastructure
All of Bioformula’s technologies are brought together in an in-house production facility spanning over 40,000 m², one of the most advanced in the world in the field of medical devices for aesthetic medicine.
Each batch is subject to monitoring and full traceability systems prior to release.
Our certifications:
“We don’t want to stop time, but to put it at the service of beauty”